Extracellular Matrix Mimics Using Hyaluronan-Based Biomaterials

The extracellular matrix is composed of hyaluronan different molecular weights that play roles in cellular proliferation, migration, and differentiation. dysregulated accumulation alters the mechanical biochemical properties it associated with several pathological states. Biomaterials can be engineered using native backbone or chemically modified to target cells via specific receptors, such as CD44. 2D surfaces controlled topography 3D hydrogels tuned composition designed mimic bioactivity this glycosaminoglycan ECM. Hyaluronan (HA) a critical element (ECM). regulated synthesis degradation HA modulates ECM chemical physical that, turn, influence behavior. triggers signaling pathways adhesion, differentiation cells, mediated by its interaction receptors tuning This review summarizes recent advances on strategies used present study healthy includes development HA-based vitro tissue models for seeding encapsulation respectively, particles carriers targeted delivery therapeutic agents. characteristic material/matrix related ability exert biological function. bone morphogenetic protein 6, known their induce growth cartilage, upregulating osteogenic markers mesenchymal stem cells. myoblasts cell line derived from mouse muscle tissue. calcium carbonate typically preparation nano-/microparticles inorganic templates. transmembrane surface glycoprotein link module hyaluronan. signal-regulated kinase 1 2, involved cascades regulate survival, tridimensional network proteins, glycoproteins, glycosaminoglycan, proteoglycans, cytokines provides structural support focal adhesion regulates movement remodeling cytoskeleton, crucial migration polysaccharides human tissues. binding protein, responsible functions. receptor endocytosis mediates systemic clearance synthase, enzyme production extrusion space. biological, chemical, equilibrium maintained living hyaluronan-binding proteins. hyaluronidases, an intra- assembly technique based deposition oppositely charged polyelectrolytes form multilayered thin film. lymphatic vessel endothelial hyaluronan, membrane domain. capacity material response stimulus. non-small lung cancer polyethylene glycol, hydrophilic molecule biomedical, industrial applications. polyethyleneimine, linear branched aliphatic polyamine. poly-l-lysine, positively polyelectrolyte. hyaluronan-mediated motility. regulation morphology, polarity, through activation signal transduction pathways. reactive oxygen species, consisting radical nonradical species. silicon dioxide. small interfering RNA silencing RNA. smooth formation function cardiovascular, respiratory, digestive systems, among others. transforming factor-?1. tumor necrosis factor-stimulated gene-6. titanium toll-like located plasma (TLR 1,2,4,5, 6) membranes endosomes lysosomes (TLRs 3, 7, 8, 9), detect pathogens. yes-associated oncoprotein cytoplasm responsive external stimuli.